A Mini Review on Testicular Tissue Engineering: A Roadmap for Future Research

Document Type : Mini-Review

Authors

1 Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of medical sciences, Yazd, Iran

2 Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Abstract

Testicular tissue engineering (TTE) is an emerging interdisciplinary field combining principles of regenerative medicine, biomaterials, and stem cell therapy to address male infertility caused by testicular dysfunction. The aim of this study is to investigate recent advancements, challenges, and future directions in TTE, focusing on scaffold-based approaches, stem cell therapies, and 3D culture systems, by integrating recent studies, up to December 2024 in databases including PubMed, Scopus, and Web of Science. Search terms included “testicular tissue engineering,” “male infertility,” “spermatogenesis,” “scaffolds,” and “stem cell therapy.” Present study highlights novel strategies, such as 3D bioprinting and decellularized testicular matrices, and justifies their originality in overcoming limitations of traditional fertility preservation methods. By integrating findings from diverse academic sources, and an overview of TTE’s potential to revolutionize male reproductive health, while identifying critical areas for current theoretical gaps and future research.

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Main Subjects

Regenerative Biomedicine
Volume 1, Issue 3
July 2025
Pages 229-234

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