Mesenchymal Stem/Stromal Cells Derived Exosomes-based Therapy and Polycystic Ovary Syndrome

Document Type : Mini-Review

Authors

1 Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Andrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Infertility is defined as the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. It has involved various communities worldwide and brought social outcomes for infertile women. However, in societies in which cultural norms value being a woman more than being a mother, these outcomes are intensified and lead to complications such as married life instability, violence and isolation. The infertility rate in Iran is estimated to be about 20%, which is above the global average (12-15%). Infertility can be caused by various factors, one of the most common reasons of which is polycystic ovary syndrome (PCOS). Women with PCOS show higher levels of circulating free testosterone (CFT), postprandial glucose, fasting insulin and triglycerides as well as lower levels of sex hormone binding globulin (SHBG). Several treatment methods have been proposed to treat this syndrome, but nowadays researchers used cell therapy as the best treatment method, looking for a better way to treat it. Cell therapy is a treatment based on stem cells and mesenchymal stem/stromal cells (MSCs) are known as promising candidates for it. The secretome of these cells contains growth factors, cytokines and extracellular vesicles (exosomes, microvesicles and apoptotic bodies), which can act as a potential therapeutic tool for the treatment of female infertility.

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Regenerative Biomedicine
Volume 1, Issue 2
March 2025
Pages 135-138

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