Document Type : Review Article
Authors
1
Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2
Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3
3) Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
4
Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
5
Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Amniotic fluid (AF) serves as a protective medium for the developing fetus and is a rich source of biologically active components, including fetal stem cells and extracellular vesicles (EVs). Notably, mesenchymal stem cells (MSCs) and human amniotic epithelial cells (hAECs) in AF possess pluripotent-like characteristics, contributing to the development of therapeutic strategies.
This review aims to explore the therapeutic potential of AF-derived stem cells (AFSCs) in regenerative medicine and immunotherapy.
The review consolidates findings on the Mesenchymal Stem Cells (MSCs) and human amniotic epithelial cells (hAECs) stand out for their pluripotent-like characteristics, with hAECs originating from epiblast-derived stem cells. AF-MSCs offer several advantages over adult MSCs, addressing ethical concerns and showcasing therapeutic potential.
The distinctive biological attributes of AF, including its components and derived cells, make it a promising candidate for therapeutic applications in regenerative medicine and immunotherapy strategies. Further research is warranted to elucidate specific clinical applications and mechanisms underlying its beneficial properties.
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