Appropriate Biomaterials for Scaffold Fabrication to Induce In Vitro Spermatogenesis

Document Type : Mini-Review

Authors

Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

The contribution of male variables to cases of infertility is believed to be between 30% and 50%. In vitro spermatogenesis and male fertility preservation can be achieved by mimicking testicular natural extracellular matrices and 3-dimensional (3D) cell culture. In recent years, tissue engineering (TE) has employed novel methods for the preservation of male fertility by generating functional male reproductive cells. Scaffolds, a crucial element of TE, are created using natural or synthetic biomaterials, or a combination of both. The utilization of natural material-based scaffolds can significantly enhance the efficiency and improve in vitro spermatogenesis compared to synthetic material-based scaffolds. Only a few investigations that have focused on in vitro spermatogenesis have yielded significant quantities of mature gametes to date. Original and review articles were obtained by searching the PubMed and Google Scholar databases. The present review focuses on the natural and synthetic materials used in the process of in vitro spermatogenesis for the purpose of fertility preservation.
 

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Regenerative Biomedicine
Volume 1, Issue 2
March 2025
Pages 78-84

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