Testicular tissue and cell transplantation have been suggested as a feasible therapeutic alternative for patients whose testicular tissue was cryopreserved before beginning gonadotoxic treatments. There have been no studies that show sperm production following the transplantation of human immature testicular tissue or spermatogonial stem cells. The main obstacles to human immature testicular tissue transplantation include the maintenance of early spermatogonial populations, hypoxia and reperfusion damage, and insufficient or delayed testicular graft neovascularization. The design and development of bioengineered scaffolding that can enhance ITT grafting in several animals and support testicular cells appears to be a potential strategy for maintaining human fertility. Original and review papers were gathered by searching the PubMed and Google Scholar databases. The search terms used were 'drug delivery', 'immature testicular tissue', 'in vivo spermatogenesis', 'scaffold', 'transplantation', and a combination of words using the AND and OR functions, as well as their corresponding equivalents in Mesh. This paper summarizes the advancements achieved in animal models of fertility restoration through the release of scaffolds.
Anvari, A. and Movahedin, M. (2025). Releasing Scaffold Can Improve Spermatogenesis. Regenerative Biomedicine, 1(2), 73-77. doi: 10.22034/jrb.2025.408
MLA
Anvari, A. , and Movahedin, M. . "Releasing Scaffold Can Improve Spermatogenesis", Regenerative Biomedicine, 1, 2, 2025, 73-77. doi: 10.22034/jrb.2025.408
HARVARD
Anvari, A., Movahedin, M. (2025). 'Releasing Scaffold Can Improve Spermatogenesis', Regenerative Biomedicine, 1(2), pp. 73-77. doi: 10.22034/jrb.2025.408
CHICAGO
A. Anvari and M. Movahedin, "Releasing Scaffold Can Improve Spermatogenesis," Regenerative Biomedicine, 1 2 (2025): 73-77, doi: 10.22034/jrb.2025.408
VANCOUVER
Anvari, A., Movahedin, M. Releasing Scaffold Can Improve Spermatogenesis. Regenerative Biomedicine, 2025; 1(2): 73-77. doi: 10.22034/jrb.2025.408
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