Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences Regenerative Biomedicine 3060-7116 1 1 2024 09 01 Therapeutic Potential of Exosomes in Wound Healing with A Focus on Fibroblast-Derived Exosomes: A Mini Review 23 31 382 10.22034/jrb.2024.114 EN Niloofar Shokrollah Al-Zahra Educational and Remedial Center, Guilan University of Medical Sciences, Rasht, Iran Behrouz Aflatoonian Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Amirhossein Ahmadieh-Yazdi Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Journal Article 2024 05 01 Impaired wound healing poses a significant challenge worldwide, impacting patients' quality of life and potentially leading to disability or even mortality. Despite the great progress that has been achieved, it remains a worldwide challenge to develop effective therapeutic treatments for diabetic wounds. Exosomes, have emerged as promising therapeutic tools in wound healing due to their ability to transfer bioactive molecules, including growth factors and cytokines, to target cells. Growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF), play pivotal roles in regulating cellular responses, promoting tissue regeneration, and modulating key signaling pathways. The interplay between growth factors and signaling pathways, including MAPK, PI3K/Akt, and NF-κB, is an important step in wound healing process. In this mini-review we aim to summarize the progress of research on the use of various exosomes derived from different cell types, with a focus on fibroblast-derived exosomes in promoting wound healing. https://jrb.ssu.ac.ir/article_382_62cd08a048f47b70ee40920c648e64a6.pdf